# James Murray on Mathematical Biology

On 25 and 26 March 1981 the Royal Society of London held a discussion meeting on

*Theories of biological pattern formation*. It was organised by S Brenner, J D Murray and L Wolpert. The*Introductory Remarks*were made by James D Murray and we give below an extract from these remarks:Perhaps I should give my view of why this meeting on

*Theories of biological pattern formation*is being held now. By the mid-1970s mathematical biology or modelling (or whatever it should be called) was a well established area of research, welcomed or not. This was particularly so in North America, continental Europe and Japan. I sympathize with the lack of grateful acceptance of this panacea for biology since much of the work had (and still has) little relevance to the real biological problems that it purported to study. At several 'interdisciplinary' meetings it was clear that communication between the various groups was non-existent and, after some of the answers to questions, perhaps it was not even wanted. A reply such as, 'It's probably a secondary Hopf bifurcation in the p.d.e. parameter space' does not have biologists on the edge of their seats - unless to leave. Genuine interdisciplinary research and the use of models in general can often produce spectacular and exciting results: regeneration models and positional information theories are just two dramatic model examples. It seems that the increasing use of models in biology is inevitable. It is now less common to hear a bioscientist dismiss their use, although they may still privately do so. For those souls who are promoting the field in the face of vocal pre-prejudiced opposition and criticism there is the apt north African proverb: 'The dogs may bark but the camel train goes on'. There are many reasons for the increased involvement of mathematicians and physical scientists in the biomedical sciences - other than the increased number of jobs and grants available (at least in America). For example, there is on the one hand the genuine scientific interest and excitement of people becoming involved in new fields, and on the other, a realization that some of the traditional areas, in applied mathematics at least, are becoming moribund. Certainly from my experience in the U.S.A. and Europe, when mathematics courses are offered that discuss bio/ecological/medical modelling, students (and some of the faculty) give them substantial support. Biotechnology, of course, is not unrelated. I find that the strongest interest comes when the problems discussed are practical and real.

Mathematics-biology research, to be useful and interesting, must be relevant biologically and not obvious. Real parameter values, for example, have to be put in or assigned by real people. The best models should show how a process works and then what may follow. An acceptable first step is a model that phenomenologically describes the biology. Suggestions as to how a process works may evolve from it. Questions of model sensitivity and robustness are important. Usually in a model we require a stability of development after it has been initiated. What is neither wanted nor appreciated are models whose aims are to show to mathematical colleagues how clever the mathematics is. Nor are trite phrases that do not explain or enlighten the mechanism studied; for example, 'the system is far from thermo- dynamic equilibrium' does not explain anything, nor does 'it is an elliptical umbilical catastrophe' - that sounds more like a complicated birth by an incompetent physician. From a mathematical point of view I feel that the art of good model building relies on (i) a sound appreciation and understanding of the biological problem (not necessarily the intricate details, at least initially); (ii) a realistic mathematical representation of the important phenomena; (iii) finding the solution, quantitative if possible, of the resulting mathematical problem; and, finally and very importantly, (iv) a biological interpretation of the results with, ideally, biological insight and predictions. The mathematics is dictated by biology, not vice versa. If the mathematics is trivial, so be it. The research is not judged by mathematical standards but by different and no less demanding ones.

Last Updated August 2016